Kirmizialtin Lab

Weiwei He

Weiwei He

Research Areas:

  • Biophysics
  • Computer Simulations
  • SAXS/WAXS
  • Machine Learning
 

Weiwei He has been a postdoctoral associate in Kimizialtin Lab since 2023. Weiwei joined our lab as a PhD student in 2018 and studies the structural properties of nucleic acids interactions and structures. His current research interest lies in developing innovative methods to to investigate structural dynamics of essential biomolecules using computer simulations and machine learning. He obtained his BSc in chemistry from Southern University of Science and Technology (SUSTech), China, with focus on organocatalysis (Prof. XinYuan Liu) and nanotechnology (Prof. Limin Huang).

Publications

  1. Weiwei He, Xiangyun Qiu* and Serdal Kirmizialtin*. "Sequence-Dependent Orientational Coupling and Electrostatic Attraction in Cation-Mediated DNA–DNA Interactions". Journal of Chemical Theory and Computation, 2023, 19, 6827 (Selected as cover)

  2. Weiwei He†, Josue San Emeterio†, Michael T Woodside, Serdal Kirmizialtin* and Lois Pollack*. "Atomistic structure of the SARS-CoV-2 pseudoknot in solution from SAXS-driven molecular dynamics". Nucleic Acids Research, 2023, 20, 11332 (†Equal first author contribution)

  3. Wei-Wei He, Nawavi Naleem, Diego Kleiman, Serdal Kirmizialtin*. "Refining RNA force field with Small-Angle X-ray Scattering of Helix-Junction-Helix RNA". J. Phys. Chem. Lett., 2022, 13, 3400

  4. Yen-Lin Chen†, Wei-Wei He†, Serdal Kirmizialtin*, and Lois Pollack*. "Insights into the structural stability of major groove RNA triplexes by WAXS-guided MD simulations". Cell Reports Physical Science, 2022, 3, 7 (†Equal first author contribution)(Selected as cover)

  5. Wei-Wei He†, Anja Henning-Knechtel†, Serdal Kirmizialtin*. "Visualizing RNA Structures by SAXS-driven MD Simulations". Frontiers in Bioinformatics, 2022. (†Equal first author contribution)

  6. Wei-Wei He†, Yen-Lin Chen†, Lois Pollack*, and Serdal Kirmizialtin*. "The Structural Plasticity of Nucleic Acid Duplexes Revealed by WAXS and MD". Science Advances, 2021, 7, 17. (†Equal first author contribution)

  7. Wei-Wei He, and Serdal Kirmizialtin*. "Exploring Cation Mediated DNA Interactions Using Computer Simulations". International Conf erence on Bio and N anomaterials. Springer, Cham, 2020.

  8. Jin-Shun Lin, Fu-Li Wang, Xiao-Yang Dong, Wei-Wei He, Yue Yuan, Su Chen, and Xin-Yuan Liu*. “Catalytic Asymmetric Radical Aminoperfluoroalkylation and Aminodifluoromethylation of Alkenes with Fluoroalkylsulfonyl Chlorides: A Versatile Platform for Enantioenriched β-Fluoroalkyl Amines”. Nature Communications, 2017, 8, 14841.

  9. Ming-Yue Wu, Wei-Wei He, Xin-Yuan Liu*, and Bin Tan*. “Asymmetric Construction of Spirooxindoles via Organocatalytic Multicomponent Reactions of Diazooxindoles”. Angew. Chem. Int. Ed., 2015, 54, 9409